Kevin A Hildebrand Selected Research

Mast Cell Stabilizers

1/2021	The Dose-Response Effect of the Mast Cell Stabilizer Ketotifen Fumarate on Posttraumatic Joint Contracture: An in Vivo Study in a Rabbit Model.
2/2020	PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) - protocol for a multicenter randomized clinical trial.
4/2012	The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures.
6/2010	The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures.
3/2008	The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs.

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Kevin A Hildebrand Research Topics

Disease

17	Contracture 01/2021 - 02/2004
7	Fibrosis (Cirrhosis) 02/2020 - 03/2008
2	Elbow Fractures 12/2020 - 01/2020
2	Wounds and Injuries (Trauma) 01/2020 - 03/2008
1	Rupture 10/2021
1	Infections 01/2017
1	Rheumatoid Arthritis 01/2017
1	Tendon Injuries 11/2010
1	Hyperplasia 06/2010

Drug/Important Bio-Agent (IBA)

7	Ketotifen (Ketotifene)FDA Link 01/2021 - 03/2008
5	Mast Cell StabilizersIBA 01/2021 - 03/2008
5	NeuropeptidesIBA 02/2020 - 10/2008
5	CollagenIBA 04/2012 - 10/2005
5	Messenger RNA (mRNA)IBA 04/2012 - 10/2005
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2013 - 03/2007
3	Tryptases (Tryptase)IBA 01/2020 - 04/2012
2	Substance PIBA 01/2021 - 11/2013
2	Proteins (Proteins, Gene)FDA Link 04/2012 - 02/2004
2	DecorinIBA 05/2006 - 10/2005
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Nerve Growth Factor (NGF)IBA 11/2013
1	Transforming Growth Factor beta (TGF-beta)IBA 11/2013
1	Connective Tissue Growth FactorIBA 03/2007
1	Fibronectins (Fibronectin)IBA 03/2007
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/2007
1	LumicanIBA 05/2006
1	Tissue Inhibitor of Metalloproteinase-1IBA 05/2006
1	Matrix Metalloproteinases (MMPs)IBA 10/2005
1	BiglycanIBA 10/2005
1	Capsules (Microcapsules)IBA 02/2004

Therapy/Procedure

2	Therapeutics 03/2017 - 02/2004
1	Early Ambulation 10/2021
1	Activities of Daily Living (ADL) 01/2021
1	Replantation 01/2017
1	Arthroplasty 01/2017
1	Sutures (Suture) 11/2010